1. PrimeGut
by PrimeGut

Owned by the Smarter Reviews Group of Companies

a+

OVERALL GRADE

PROS

  • 18 plant-based enzymes
  • Saccharomyces boulardii
  • Doctor-formulated
  • 100% natural, vegetarian formula
  • 90-day 100% money-back return policy
  • Made in the USA with globally sourced ingredients

CONS

  • Due to popular demand, frequently out of stock

The Bottom Line

We chose EnzymeMD® by 1MD NutritionTM because it's the only supplement that meets our criteria.

Its doctor-formulated blend includes 18 plant-based enzymes that naturally help break down nutrients. We also confirmed that it contains Saccharomyces boulardii to help boost digestion over the long term. The formula is free of dangerous additives. It's also non-GMO.

1MD Nutrition's return policy was also more generous than others we reviewed, and their customer service department was knowledgeable and easy to reach. They confirmed that their product is made in the USA and 100% vegan. We not only felt comfortable with their ingredients and potency, but we also loved that the brand is devoted to educating the public about their health. With all this in mind, we decided to put EnzymeMD® by 1MD NutritionTM at the top of our list.

*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.

2. DigestWell
by Live Conscious

Owned by the Smarter Reviews Group of Companies

a-

OVERALL GRADE

PROS

  • Contains a high concentration of Protease
  • Strong 365-day return policy
  • 100% vegetarian, organic
  • Made in the USA with globally sourced ingredients

CONS

  • Not formulated by a gastroenterologist

The Bottom Line

Live Conscious' DigestWell was the obvious pick for our #2 because it contains 10 broad spectrum, plant-based digestive enzymes that have each been shown to help you absorb key nutrients and improve your digestion.

The addition of the clinically studied probiotic DE111® and powerful botanicals, ginger, fennel, and peppermint, all clinically proven to aid in digestion, also bring quick relief to the uncomfortable symptoms related to indigestion. Many customers said they saw quicker results after increasing their daily dosage by 2 to 3 capsules.*

*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.

3. Digest Gold
by Live Conscious

Owned by the Smarter Reviews Group of Companies

c-

OVERALL GRADE

PROS

  • Many positive customer reviews
  • Potent enzymes
  • Free of fillers and additives

CONS

  • Short return policy

While Digest Gold by Enzymedica gets rave customer reviews, we were wary of putting it anywhere above our #3 spot. This was mainly due to their extremely limited return policy. This makes us worried that they don't have as much faith in their product as they claim. On the bright side, the product does contain a potent serving of enzymes. All in all, while Digest Gold is a strong contender, but we couldn't put it higher than #3 on our list.

*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.

4. Unbloat
by Unbloat

Owned by the Smarter Reviews Group of Companies

b

OVERALL GRADE

PROS

  • 21 enzymes
  • Potent enzymes
  • Made in the USA with globally sourced ingredients

CONS

  • Short return policy

Unbloat is a doctor-formulated enzyme blend with probiotics, herbs, and even prebiotic fiber. Although it’s packed with a variety of ingredients, it can be hard to tell what is actually giving you the benefits vs. any unwanted side effects like some reviewers experienced.

The company doesn’t reveal if the enzymes are made from animals or plants. The other downside is that it contains several probiotics that may interfere with the digestive enzymes’ effectiveness. It also only has a 30 day money back guarantee. With all of this in mind, we put Unbloat in fourth place.

*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.

5. Fodzyme
by Kiwi Biosciences

Owned by the Smarter Reviews Group of Companies

C-

OVERALL GRADE

PROS

  • 3 enzyme formula for foods high in FODMAPs
  • Made in the USA with globally sourced ingredients

CONS

  • Not broad-spectrum
  • Not backed by a doctor
  • Short return policy
  • Consumers may not like its powder form

Fodzyme is specifically made to help you digest food high in FODMAPs which are types of carbohydrates strongly linked to digestive discomfort and worries. And since it’s not broad-spectrum, it won’t break down most foods you eat in a meal. In fact, it doesn’t even help you digest polyols — the “P” in FODMAPs.

The most unique aspect of Fodzyme is that it doesn’t come in a capsule. It comes in a powder form that you have to sprinkle on top of high FODMAP foods.

Unfortunately, it’s not formulated by a doctor and it only has a 30-day money-back guarantee. All in all, Fodzyme still has a good customer review rating and for that reason, we placed it fifth.

*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.

1. Digestive Enzyme Supplementation in Gastrointestinal Diseases, Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini, and Giovanni Cammarota, Curr Drug Metab. 2016 Feb; 17(2): 187–193. Published online 2016 Feb. doi: 10.2174/138920021702160114150137

2. Patel RS, Johlin FC Jr, Murray JA. Celiac disease and recurrent pancreatitis. Gastrointest Endosc 1999;50:823-7.

3. Hegnhoj J, Hansen CP, Rannem T, et al. Pancreatic function in Crohn's disease. Gut 1990;31:1076-9.

4. Suarez F, Levitt MD, Adshead J, Barkin JS. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal. Dig Dis Sci 1999;44:1317-21.

5. Nakamura T, Tandoh Y, Terada A, et al. Effects of high-lipase pancreatin on fecal fat, neutral sterol, bile acid, and short-chain fatty acid excretion in patients with pancreatic insufficiency resulting from chronic pancreatitis. Int J Pancreatol 1998;23:63-70.

6. Taylor CJ, Hillel PG, Ghosal S, et al. Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis. Arch Dis Child 1999;80:149-52.

7. Patel RS, Johlin FC Jr, Murray JA. Celiac disease and recurrent pancreatitis. Gastrointest Endosc1999;50:823-7.4. Gullo L. Indication for pancreatic enzyme treatment in non-pancreatic digestive diseases. Digestion1993;54(suppl 2):43-7.

8. Suarez F, Levitt MD, Adshead J, Barkin JS. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal. Dig Dis Sci 1999;44:1317-21.

9. Layer P, Groger G. Fate of pancreatic enzymes in the human intestinal lumen in health and pancreatic insufficiency. Digestion 1993;54(suppl 2):10-4.

10. Stevens JC, Maguiness KM, Hollingsworth J, et al. Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy. J Pediatr Gastroenterol Nutr 1998;26:80-4.

11. Oades PJ, Bush A, Ong PS, Brereton RJ. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet 1994;343:109 [letter].

12. Campbell CA, Forrest J, Muscgrove C. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet 1994;343:109-10 [letter].

13. Milla CE, Wielinski CL, Warwick WJ. High-strength pancreatic enzymes. Lancet 1994;343:599 [letter].

14. Jones R, Franklin K, Spicer R, Berry J. Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet 1995;346:499-500 [letter].

15. Powell CJ. Pancreatic enzymes and fibrosing colonopathy. Lancet 1999;354:251 [letter].

16. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients, Lynne V McFarland, World J Gastroenterol. 2010 May 14; 16(18): 2202–2222. Published online 2010 May 14. doi: 10.3748/wjg.v16.i18.2202